A Question about Super Virtual Resolution in games.

I have dual 1920x1080 monitors, and I do like to play at 1440p(downsampling) on some of my games by downsampling. My question is If I set the actual monitor resolution in the display settings from 1920x1080 to 2560x1440 resolution, does this affect my game's image quality in downsampling when playing in SVR game 1440p? I would just keep my monitor's native resolution at 1920x1080 but I get problems sometimes  when alt tabbing out of games where I guess the GPU glitches out and and locks up when alt tabbing back into the game.